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Mortality After GI bleed Catheter Embolisation (MAGIC Embo)
Project Summary
Acute non-variceal lower gastrointestinal (GI) bleeding is a common medical emergency associated with high hospitalisation rates and mortality of up to 10%. While transcatheter arterial embolisation is an established, minimally invasive alternative to surgery, there is a lack of risk stratification tools to guide patient selection, unlike the established pathways for endoscopy. This represents a significant clinical gap in optimising care for these critically ill patients.
This study aims to analyse the current practice of emergency embolisation for lower tract GI bleeding to better understand predictors of outcomes and improve emergency management.
The details
Study design
Muticentre retrospective study
Inclusion Criteria
Exclusion criteria
Adult Patients undergoing emergency embolisation for non-variceal lower GI bleeding. Date of procedure XX/XX/XX - XX/XX/XX.
Patients who underwent embolisation for variceal GI bleeding, upper GI bleeding, chronic GI bleeding > 30 days.
Sample size
30 local patients with contributions from other centres in the UK (minimum 800 patients expected)
Follow-up Duration
6 months from date of procedure or date of death, whichever is sooner
Planned Study Period
24 months
Primary objective
Not calculated
To establish the rates of rebleeding, reintervention, embolisation
failure, and complications following emergency embolisation.
Team and funding
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​Chief Investigator:
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Dr Deevia Kotecha – Interventional Radiology Registrar and Honorary Research Fellow, University Hospital Plymouth NHS Trust, UK
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Co-investigators:
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Dr Noemi Cinti, Foundation Year 1 Doctor, The Royal Wolverhampton NHS Trust, UK
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Dr Vinson Wai-Shun Chan, Radiology Registrar, Leeds Teaching Hospitals NHS Trust, UK
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Dr Indrajeet Mandal, Interventional Radiology Registrar, Oxford Deanery, UK
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Professor Ganesh Vigneswaran, Professor of Interventional Radiology and Medical AI and Consultant Vascular Interventional Radiologist, University Hospitals of Dorset, UK
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Dr Raghuram Lakshminarayan, Consultant Vascular Interventional Radiologist, Hull University Teaching Hospitals, UK
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Dr Paul Jenkins, Consultant Vascular Interventional Radiologist, University Hospitals Plymouth NHS Trust, Plymouth, UK
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Ethics and Funding
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The retrospective observational study will be conducted in compliance with the principles of the ICH GCP guidelines and in accordance with all applicable regulatory guidance including, but not limited to the UK Policy Framework for Health and Social Care research.
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This project is supported by a British Society of Interventional Radiology Research Grant and by the Guts UK Charity.
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